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Prednisone (10mg) drug has anti-inflammatory, anti-allergic, anti-shock effect. When this drug is administered parenterally, these effects are carried out through mechanisms common to all glucocorticosteroids, reducing capillary permeability, etc. After taking Prednisone (10mg), the synthesis and secretion of adrenocorticotropic hormone of the pituitary gland and, as a result, glucocorticosteroids in the adrenal glands are blocked in the human body..

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When taking Prednisone (10mg) it is absorbed in the digestive system. In this case, the maximum concentration in human blood plasma is reached after 90 minutes. Prednisolone is metabolized primarily in the patient's liver. In the case of intramuscular and intravenous administration of glucocorticosteroids, their effect is less than when the drug is taken orally.

When specialists in rheumatology recommend Prednisone (10mg), at the beginning of treatment, they use the drug in high doses, of course, according to the severity of the disease, and then gradually reduce the dose of the drug.

The drug Prednisone (20mg) is more than effective when it is used during the inflammatory process with high activity. Thus, the use of acetylsalicylic acid is more justified than the use of prednisolone with the activity of rheumatism of the I degree. With stage II-III disease activity, significantly prednisolone

Prednisone Indications

Indications for the use of Prednisone are:

  • rheumatoid arthritis,
  • acute rheumatic fever,
  • Addison's disease,
  • acute adrenal insufficiency,
  • adrenogenital syndrome,
  • bronchial asthma (including for the elimination of status asthma),
  • acute and chronic allergic diseases (drug allergy),
  • urticaria,
  • allergic rhinitis,
  • hypersensitivity to various chemicals,
  • Quincke's edema,
  • hepatitis,
  • hepatic coma,
  • hypoglycemic state,
  • lipoid nephrosis,
  • blood system diseases (agranulocytosis, various forms of leukemia),
  • thrombocytopenic purpura,
  • hemolytic disease,
  • connective tissue diseases systemic red lupus,
  • dermatomyositis,
  • polymyositis,
  • periarteritis nodosa and other systemic vasculitis,
  • severe skin diseases (pemphigus, eczema, exfoliative dermatitis, psoriasis),
  • visual diseases iridocyclitis, uveitis, choroiditis.

Prednisone is also used in pediatrics for the following diseases: acute rheumatic fever, small chorea, obstructive bronchitis, nephrotic syndrome, to suppress the rejection reaction during organ and tissue transplantation.

Prednisone dosage and methods of administration

The dose of Prednisone is determined after examining the patient, the dose for each is highly individual. In acute cases, adults are prescribed Prednisone 20-30 mg daily as an initial dose, but it can be increased to 100 mg/day, the maintenance dose is 5-10 mg/day.

As a rule, for parenteral administration (intramuscular and intravenous), the dose, frequency and duration of drug administration are also determined for each person in a strictly individual manner. Usually 30-45 mg of Prednisone is injected very slowly into the patient. According to the instructions, this dose can be changed to 30-60 mg.

side effect

Naturally, Prednisone also has side effects that can cause serious harm

For example it can cause:

  • Dysfunction of the gastrointestinal tract: irritating effect on the mucous membrane. That's why experts recommend taking Prednisone after meals.
  • development of osteoporosis - glucocorticosteroids disrupt the exchange of calcium in the body, contributing to the loss of bones, which unfortunately leads to a decrease in their density and an increase in fragility in the body.
  • increased body weight, with a specific increase in trunk and facial fat and a decrease in the limbs
  • fluid retention in the body, which can be manifested by swelling and increase the level of blood pressure in the human body.

This is related to the effect of glucocorticosteroids on water-salt metabolism. That is why it is necessary to control the water balance. After consulting a doctor, take pills containing diuretic properties. And if it turns out that the measures taken do not normalize the blood pressure level, in this case, you must take antihypertensive drugs, of course, according to the doctor's prescription.